Fabrication of DNA‐based Biosensors Driven by Electrostatic Attractions on Electrodes Modified with Reduced Graphene Oxide and Multi‐walled Carbon Nanotubes

The use of reduced graphene oxide (rGO) and multi-walled carbon nanotubes (MWCNTs) has attracted considerable interest for fabrication chemical sensors biosensors in recent years. In this study, we report on two ultrasensitive DNA based a sensing mechanism driven by the electrostatic attraction [Ru(NH3)6]3+ cations electrode surfaces modified with Au-MWCNTs Au-rGO. A one-step pot synthesis was used to prepare these nanocomposites development DNA-based biosensors. detection anionic phosphate backbone DNA. interfacial changes surface upon hybridisation were detected differential pulse voltammetry (DPV). high conductivity volume ratio properties materials enabled significant enhancement response target detection. DPV gave linear concentration ranges (LCRs) 0.1–10,000 pM 1–100 Au-MWCNT Au-rGO-based biosensors, respectively. Thus, indicating that MWCNT-based biosensor more sensitive achieved wider LCR. Nevertheless, both MWCNT rGO-based exhibited very good discrimination against mismatch sequences.